The objective of this contract is to establish a Registry of radiation therapy complications of organs in which radiation therapy injuries are either fatal or result in severe morbidity. Both prospective and retrospective information shall be gathered and where possible an attempt to assess incidence of complications shall be made. Incidence of second cancers developing within and outside of irradiated tissue shall be studied. Prospective information shall be accumulated on irradiation of selected organs to determine the probability of injury developing at various radiation doses and the influence of other treatment modalities on this risk. Predictive models shall be developed. 10,000 patient cases annually will be registered with 1,000 of these being Phase III patient cases.